Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats

Eur J Pharmacol. 2004 Sep 13;498(1-3):153-6. doi: 10.1016/j.ejphar.2004.07.001.


We examined the potential anxiolytic-like activity of (-)-N-phenyl-7-(hydroxyimino) cyclopropa[b]chromen-1a-carboxamide (PHCCC), an allosteric modulator of metabotropic glutamate4 receptors (mGlu4), after administration into the basolateral amygdala, using the conflict drinking Vogel test in rats as a model. The results indicate that PHCCC, but not 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt), the selective antagonist of group mGlu1 receptors, showed significant, dose-dependent anticonflict effects without affecting the threshold current or water intake. The results indicate that positive allosteric modulation of mGlu4 receptors may be a useful therapeutic approach to anxiety.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Drinking
  • Allosteric Regulation
  • Amygdala / drug effects
  • Analysis of Variance
  • Animals
  • Anti-Anxiety Agents / pharmacology*
  • Anxiety / prevention & control
  • Behavior, Animal / drug effects
  • Benzopyrans / pharmacology*
  • Chromones / pharmacology
  • Conflict, Psychological
  • Dose-Response Relationship, Drug
  • Drinking Behavior / drug effects
  • Electroshock
  • Male
  • Rats
  • Rats, Wistar
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors
  • Receptors, Metabotropic Glutamate / chemistry
  • Receptors, Metabotropic Glutamate / metabolism*


  • 7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester
  • Anti-Anxiety Agents
  • Benzopyrans
  • Chromones
  • N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide
  • Receptors, Metabotropic Glutamate
  • metabotropic glutamate receptor type 1
  • metabotropic glutamate receptor 4