The centrosome in higher organisms: structure, composition, and duplication

Int Rev Cytol. 2004;238:119-82. doi: 10.1016/S0074-7696(04)38003-4.

Abstract

The centrosome found in higher organisms is an organelle with a complex and dynamic architecture and composition. This organelle not only functions as a microtubule-organizing center, but also is integrated with or impacts a number of cellular processes. Defects associated with this organelle have been linked to a variety of human diseases including several forms of cancer. Here we review the emerging picture of how the structure, composition, duplication, and function of the centrosome found in higher organisms are interrelated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • A Kinase Anchor Proteins
  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Antigens / metabolism
  • Cell Division / physiology
  • Cell Nucleus / metabolism
  • Cell Nucleus / ultrastructure
  • Centrosome* / metabolism
  • Centrosome* / ultrastructure
  • Chromosomes / metabolism
  • Chromosomes / ultrastructure
  • Chromosomes, Mammalian / metabolism
  • Chromosomes, Mammalian / ultrastructure
  • Cytoskeletal Proteins / metabolism
  • Humans
  • Microtubule-Associated Proteins / metabolism
  • Microtubules / metabolism
  • Molecular Motor Proteins / metabolism
  • Phosphoprotein Phosphatases / metabolism
  • Protein Kinases / metabolism

Substances

  • A Kinase Anchor Proteins
  • AKAP9 protein, human
  • Adaptor Proteins, Signal Transducing
  • Antigens
  • Cytoskeletal Proteins
  • Microtubule-Associated Proteins
  • Molecular Motor Proteins
  • pericentrin
  • Protein Kinases
  • Phosphoprotein Phosphatases