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, 18 (3), 75-9

Opioid Insights:opioid-Induced Hyperalgesia and Opioid Rotation

  • PMID: 15364634

Opioid Insights:opioid-Induced Hyperalgesia and Opioid Rotation

Perry G Fine. J Pain Palliat Care Pharmacother.


Opioid analgesics are an irreplaceable component of pharmacotherapy of numerous pain-producing conditions. Clinicians and patients must contend with the imperfect nature of this class of drugs, trying to balance benefits and burdens on a continual basis. New literature related to evidence-based selection of opioids and the neurobiological phenomenon of opioid induced hyperalgesia are reviewed. A matrix describing critical elements in the selection of opioid analgesics, both for initial therapy and for opioid rotation, is presented.

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