Detection of hepatitis A virus RNA in saliva

J Clin Microbiol. 2004 Sep;42(9):4329-31. doi: 10.1128/JCM.42.9.4329-4331.2004.


Hepatitis A virus (HAV) is shed in feces but also in saliva. HAV RNA was detected in saliva in five out of six acutely infected patients with HAV viremia. Serum and saliva sequences were identical. The simplicity of obtaining material allows the recommendation of the use of saliva for investigation of outbreaks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Disease Outbreaks
  • Female
  • Hepatitis A / blood
  • Hepatitis A / diagnosis*
  • Hepatitis A virus / classification
  • Hepatitis A virus / isolation & purification*
  • Humans
  • Male
  • Middle Aged
  • Phylogeny
  • RNA, Viral / analysis*
  • RNA, Viral / blood
  • Reproducibility of Results
  • Saliva / virology*


  • RNA, Viral