Abstract
Using H2(15)O PET, the authors imaged 13 patients with Alzheimer disease (AD) while performing a serial nonverbal recognition memory task. Patterns of brain activation differed as a function of APOE genotype: epsilon4 carriers exhibited lower activation in the left lingual gyrus and higher activation in left cuneus, precuneus, parahippocampal, and right precentral gyrus. The APOE genotype seems to play a role in cerebral physiologic activity even after onset of clinical manifestations of AD.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Age of Onset
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Alleles
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Alzheimer Disease / diagnostic imaging
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Alzheimer Disease / epidemiology
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Alzheimer Disease / genetics
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Alzheimer Disease / physiopathology*
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Apolipoprotein E4
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Apolipoproteins E / genetics
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Apolipoproteins E / physiology*
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Brain / diagnostic imaging
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Brain / physiopathology*
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Brain Mapping*
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Female
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Genotype
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Humans
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Male
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Memory Disorders / diagnostic imaging
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Memory Disorders / genetics
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Memory Disorders / physiopathology
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Mental Recall
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Middle Aged
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Neuropsychological Tests
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Pattern Recognition, Visual
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Positron-Emission Tomography*
Substances
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Apolipoprotein E4
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Apolipoproteins E