Prognostic value of morphology and hormone receptor status in breast cancer - a population-based study

Br J Cancer. 2004 Oct 4;91(7):1263-8. doi: 10.1038/sj.bjc.6602153.


We analysed the 5-year relative survival among 4473 breast cancer cases diagnosed in 1990-1992 from cancer registries in Estonia, France, Italy, Spain, the Netherlands and the UK. Among eight categories based on ICD-O codes (infiltrating ductal carcinoma, lobular plus mixed carcinoma, comedocarcinoma, 'special types', medullary carcinoma, not otherwise specified (NOS) carcinoma, other carcinoma and cancer without microscopic confirmation), the 5-year relative survival ranged from 66% (95% CI 61-71) for NOS carcinoma to 95% (95% CI 90-100) for special types (tubular, apocrine, cribriform, papillary, mucinous and signet ring cell); 27% (95% CI 18-36) for cases without microscopic confirmation. Differences in 5-year relative survival by tumor morphology and hormone receptor status were modelled using a multiple regression approach based on generalised linear models. Morphology and hormone receptor status were confirmed as significant survival predictors in this population-based study, even after adjusting for age and stage at diagnosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Breast Neoplasms / pathology*
  • Carcinoma, Ductal, Breast / pathology*
  • Carcinoma, Lobular / pathology*
  • Europe
  • Female
  • Humans
  • Middle Aged
  • Prognosis
  • Receptors, Estrogen / analysis*
  • Receptors, Progesterone / analysis*
  • Registries / statistics & numerical data*
  • Risk Factors
  • Survival Analysis


  • Receptors, Estrogen
  • Receptors, Progesterone