Intermediate filaments mediate cytoskeletal crosstalk

Nat Rev Mol Cell Biol. 2004 Aug;5(8):601-13. doi: 10.1038/nrm1438.


Intermediate filaments, actin-containing microfilaments and microtubules are the three main cytoskeletal systems of vertebrate and many invertebrate cells. Although these systems are composed of distinctly different proteins, they are in constant and intimate communication with one another. Understanding the molecular basis of this cytoskeletal crosstalk is essential for determining the mechanisms that underlie many cell-biological phenomena. Recent studies have revealed that intermediate filaments and their associated proteins are important components in mediating this crosstalk.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actin Cytoskeleton / physiology
  • Animals
  • Cytoskeleton / physiology*
  • Intermediate Filaments / physiology*
  • Microtubules / physiology
  • Models, Biological
  • Signal Transduction / physiology*