The co-workers of actin filaments: from cell structures to signals

Nat Rev Mol Cell Biol. 2004 Aug;5(8):635-46. doi: 10.1038/nrm1437.


Cells have various surface architectures, which allow them to carry out different specialized functions. Actin microfilaments that are associated with the plasma membrane are important for generating these cell-surface specializations, and also provide the driving force for remodelling cell morphology and triggering new cell behaviour when the environment is modified. This phenomenon is achieved through a tight coupling between cell structure and signal transduction, a process that is modulated by the regulation of actin-binding proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / physiology*
  • Actin Cytoskeleton / ultrastructure
  • Actins / physiology*
  • Actins / ultrastructure*
  • Animals
  • Cell Differentiation
  • Microfilament Proteins / physiology
  • Models, Biological
  • Morphogenesis
  • Signal Transduction / physiology*


  • Actins
  • Microfilament Proteins