Nerve growth factor in the synovial fluid of patients with chronic arthritis

Arthritis Rheum. 1992 Mar;35(3):351-5. doi: 10.1002/art.1780350315.


Cytokines regulate nerve growth factor (NGF) synthesis during inflammatory processes. Since cytokines are also involved in the inflammatory processes of autoimmune rheumatic diseases, we examined levels of NGF in patients with rheumatoid or other types of chronic arthritis. NGF was present in the synovial fluid and synovium of patients with chronic arthritis, but was undetectable in control fluids. We conclude that NGF might be involved in the pathogenesis of arthritis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Arthritis / metabolism*
  • Chronic Disease
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nerve Growth Factors / analysis*
  • Synovial Fluid / chemistry*
  • Synovial Membrane / chemistry


  • Nerve Growth Factors