Disaccharide analysis of the skin glycosaminoglycans in systemic sclerosis

Br J Dermatol. 1992 Jan;126(1):29-34. doi: 10.1111/j.1365-2133.1992.tb08399.x.


The disaccharides constituting chondroitinase-digestible glycosaminoglycan (GAG) in the skin lesions of patients with systemic sclerosis were determined using high-performance liquid chromatography (HPLC). In scleroderma there was an increase in the amount of delta Di-4S(DS), the main disaccharide unit of dermatan sulphate, and a decrease in delta Di-HA, the disaccharide unit of hyaluronic acid, as compared with normal skin from a similar site. The distribution pattern of the main disaccharides constituting chondroitin sulphate and dermatan sulphate in scleroderma differed from that in scars or scleredema.

MeSH terms

  • Adult
  • Aged
  • Chondroitin Sulfates / analysis
  • Chromatography, High Pressure Liquid
  • Dermatan Sulfate / analysis
  • Disaccharides / analysis*
  • Female
  • Glycosaminoglycans / analysis*
  • Humans
  • Hyaluronic Acid / analysis
  • Male
  • Middle Aged
  • Scleroderma, Systemic*
  • Skin / chemistry*


  • Disaccharides
  • Glycosaminoglycans
  • Dermatan Sulfate
  • Hyaluronic Acid
  • Chondroitin Sulfates