Severe sinus bradycardia after initiation of bupropion therapy: a probable drug-drug interaction with metoprolol

David L McCollum; Jerica L Greene; Darren K McGuire

doi:10.1023/B:CARD.0000041254.15807.98

Severe sinus bradycardia after initiation of bupropion therapy: a probable drug-drug interaction with metoprolol

Cardiovasc Drugs Ther. 2004 Jul;18(4):329-30. doi: 10.1023/B:CARD.0000041254.15807.98.

Authors

David L McCollum¹, Jerica L Greene, Darren K McGuire

Affiliation

¹ Department of Internal Medicine, The University of Texas-Southwestern Medical Center at Dallas, Dallas,Texas, USA. ren.mcguire@southwestern.edu

PMID: 15367832
DOI: 10.1023/B:CARD.0000041254.15807.98

Abstract

Bupropion is an increasingly prescribed agent to aid in smoking cessation. However it has important drug-drug interactions related to the cytochrome P450 system. One of these is its inhibition of the metabolism of the commonly used beta-blocker, metoprolol. The authors describe a case of severe bradycardia related to the addition of bupropion to the medical regimen of a patient on metoprolol.

Publication types

Case Reports

MeSH terms

Adrenergic beta-Antagonists / adverse effects*
Arrhythmia, Sinus / chemically induced*
Bradycardia / chemically induced*
Bupropion / adverse effects*
Dopamine Uptake Inhibitors / adverse effects*
Drug Interactions
Humans
Hypertension / drug therapy
Male
Metoprolol / adverse effects*
Middle Aged
Severity of Illness Index
Smoking Cessation

Substances

Adrenergic beta-Antagonists
Dopamine Uptake Inhibitors
Bupropion
Metoprolol