[Use of MBDS as a tool for the detection of drug-related adverse events]

Farm Hosp. 2004 Jul-Aug;28(4):258-65.
[Article in Spanish]


Objective: To analyze drug-related adverse events (DRAE) as noted in hospital discharge reports, as well as their severity and drugs involved, and to assess potential avoidability.

Material and methods: A retrospective study for the September-December 2002 period of time in which patients with discharge reports including an ICD-9-CM code E930-E949.9 were selected using the minimum basic data set (MBDS).

Results: DRAEs were detected in 2.15% of all discharge reports, and 229 were retrospectively assessed. In all, 62.45% (n = 143) were DRAEs detected at the Emergency Department, and 37.55% (n = 86) were DRAEs detected during hospitalization. Of these, 57.20% are considered potentially avoidable. Drugs most commonly involved in the outpatient DRAE sample studied included: digoxin (24.47%, avoidable 97.14%) and NSAIDs-opioids (13.98%, avoidable 75%). Inpatient DRAEs included: anticoagulants (30.23%, avoidable 57.69%) and antimicrobials (17.44%, avoidable 26.67%).

Conclusions: The study revealed a high proportion of preventable DRAEs around a small number of drugs. Information to prescribing doctors and procedures for treatment follow-up using a unit dose drug dispensing system may be useful to reduce this.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Adverse Drug Reaction Reporting Systems*
  • Aged
  • Drug Therapy / statistics & numerical data
  • Drug-Related Side Effects and Adverse Reactions*
  • Emergency Service, Hospital
  • Female
  • Hospitalization
  • Humans
  • International Classification of Diseases
  • Male
  • Medical Records*
  • Medication Errors / statistics & numerical data
  • Middle Aged
  • Patient Discharge*
  • Retrospective Studies
  • Safety Management