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Review
. 2004 Oct 15;75(22):2615-9.
doi: 10.1016/j.lfs.2004.07.008.

Salvinorin A: A Novel and Highly Selective Kappa-Opioid Receptor Agonist

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Review

Salvinorin A: A Novel and Highly Selective Kappa-Opioid Receptor Agonist

Feng Yan et al. Life Sci. .

Abstract

kappa-opioid receptors (KORs) represent the principal site of action of dynorphin and related neuropeptides. Recently, Salvinorin A--a naturally occurring neoclerodane diterpene hallucinogen was identified to be a highly selective KOR agonist. In this brief review we summarize the known chemistry, pharmacology and biology of salvinorin A. Because salvinorin A profoundly alters human consciousness and perception, a study of how salvinorin A exerts its actions on KORs may yield novel insights into the molecular and cellular basis of uniquely human higher cortical functions.

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