Molecular makeup of HIV-1 envelope protein

Int Rev Immunol. Sep-Dec 2004;23(5-6):383-411. doi: 10.1080/08830180490432749.


A broad range of structural, functional, and immunological similarities between HIV-1 gp120 and human proteins, especially those participating in immune responses, highlight gp120 as a pleiotropic protein that can in different ways affect many important functions of the human immune system. Here we described some of these properties of HIV-1 gp120 that represent the main obstacle in the development of effective and safe AIDS vaccine.

Publication types

  • Review

MeSH terms

  • Collagen Type VI / chemistry
  • Cross Reactions
  • Genes, Immunoglobulin
  • HIV Envelope Protein gp120 / chemistry*
  • HIV Envelope Protein gp120 / genetics
  • HIV Envelope Protein gp120 / immunology
  • HIV-1 / chemistry*
  • Immunoglobulin Heavy Chains / chemistry
  • Immunoglobulin Heavy Chains / genetics
  • Immunoglobulin Variable Region / chemistry
  • Immunoglobulin Variable Region / genetics
  • Interleukin-2 / biosynthesis
  • Vasoactive Intestinal Peptide / chemistry


  • Collagen Type VI
  • HIV Envelope Protein gp120
  • Immunoglobulin Heavy Chains
  • Immunoglobulin Variable Region
  • Interleukin-2
  • Vasoactive Intestinal Peptide