The Functions of Animal microRNAs

Nature. 2004 Sep 16;431(7006):350-5. doi: 10.1038/nature02871.

Abstract

MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and many of these are phylogenetically conserved. With miRNA roles identified in developmental timing, cell death, cell proliferation, haematopoiesis and patterning of the nervous system, evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Genomics
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Multigene Family / genetics
  • Substrate Specificity

Substances

  • MicroRNAs