RNA silencing in plants

Nature. 2004 Sep 16;431(7006):356-63. doi: 10.1038/nature02874.


There are at least three RNA silencing pathways for silencing specific genes in plants. In these pathways, silencing signals can be amplified and transmitted between cells, and may even be self-regulated by feedback mechanisms. Diverse biological roles of these pathways have been established, including defence against viruses, regulation of gene expression and the condensation of chromatin into heterochromatin. We are now in a good position to investigate the full extent of this functional diversity in genetic and epigenetic mechanisms of genome control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism
  • Argonaute Proteins
  • Gene Expression Regulation, Plant*
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • Plants / genetics*
  • Plants / virology
  • RNA Interference / physiology*
  • RNA, Plant / genetics
  • RNA, Plant / metabolism*
  • Ribonuclease III / genetics
  • Ribonuclease III / metabolism


  • AGO1 protein, Arabidopsis
  • Arabidopsis Proteins
  • Argonaute Proteins
  • MicroRNAs
  • RNA, Plant
  • Ribonuclease III