Cost-effectiveness analysis of Malaysian neonatal intensive care units

J Perinatol. 2005 Jan;25(1):47-53. doi: 10.1038/


Objective: To perform a cost-effective analysis on the care of infants between 1000 and 1500 g birthweight (the study group), where outcomes are measured as survival to 1 year of age.

Methodology: This was a multicenter observational study to determine the outcome, cost and cost-effectiveness of neonatal intensive care provided by Ministry of Health (MOH) Pediatric services. A total of 333 patients enrolled were eligible for analysis according to the inclusion and exclusion criteria of this study.

Results: Overall survival probability of the study group infants at 1 year of age was 78%. Survival at 1-year of age was 77% for infants with birth weight 1000 to 1249 g, 79% for 1250 to 1499 g. Survival at 1 year of age for the sample group was 53% for 22 to 27 weeks gestation, 80% for 28 to 36 weeks. The average cost-effectiveness ratio (CER) of neonatal intensive care for the study group infants was US$3979 [corrected] per survivor at 1 year of age (95% confidence interval US$3411, 5160).

Conclusion: There was variability in the outcome and cost-effectiveness between the neonatal units, which need to be further assessed. However, neonatal intensive care services provided for the study group infants were cost-effective compared to that in developed countries.

Publication types

  • Multicenter Study

MeSH terms

  • Cost-Benefit Analysis
  • Direct Service Costs*
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Very Low Birth Weight*
  • Intensive Care, Neonatal / economics*
  • Length of Stay / economics
  • Malaysia
  • Observation
  • Retrospective Studies
  • Survival Rate
  • Treatment Outcome