Most effective stimulation site in subthalamic deep brain stimulation for Parkinson's disease

Mov Disord. 2004 Sep;19(9):1050-4. doi: 10.1002/mds.20056.


The optimal stimulation site in subthalamic deep brain stimulation (STN-DBS) was evaluated by correlation of the stereotactic position of the stimulation electrode with the electrophysiologically specified dorsal STN border. In a series of 25 electrodes, best clinical results with least energy consumption were found in contacts located in the dorsolateral border zone, whereas contacts within the subthalamic white matter, e.g., zona incerta, were significantly less effective. We suggest that the dorsolateral STN border should be covered by STN-DBS.

Publication types

  • Clinical Trial

MeSH terms

  • Electric Stimulation Therapy / instrumentation*
  • Electrodes, Implanted
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Parkinson Disease / pathology
  • Parkinson Disease / therapy*
  • Retrospective Studies
  • Substantia Nigra / pathology
  • Subthalamic Nucleus / pathology
  • Subthalamic Nucleus / physiology*