A Walk-Through of the Yeast Mating Pheromone Response Pathway

Peptides. 2004 Sep;25(9):1465-76. doi: 10.1016/j.peptides.2003.10.022.

Abstract

The intracellular signal transduction pathway by which the yeast Saccharomyces cerevisiae responds to the presence of peptide mating pheromone in its surroundings is one of the best understood signaling pathways in eukaryotes, yet continues to generate new surprises and insights. In this review, we take a brief walk down the pathway, focusing on how the signal is transmitted from the cell-surface receptor-coupled G protein, via a MAP kinase cascade, to the nucleus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Membrane / metabolism
  • GTP-Binding Proteins / chemistry
  • Genes, Fungal*
  • Humans
  • MAP Kinase Kinase Kinases / metabolism
  • MAP Kinase Signaling System / physiology
  • Models, Biological
  • Peptides / chemistry
  • Pheromones / chemistry
  • Protein Binding
  • Protein Structure, Tertiary
  • Saccharomyces cerevisiae / physiology*
  • Saccharomyces cerevisiae Proteins / physiology*
  • Signal Transduction

Substances

  • Peptides
  • Pheromones
  • Saccharomyces cerevisiae Proteins
  • MAP Kinase Kinase Kinases
  • Ste11 protein, S cerevisiae
  • GTP-Binding Proteins