Effect of oral L-arginine on oxidant stress, endothelial dysfunction, and systemic arterial pressure in young cardiac transplant recipients

Am J Cardiol. 2004 Sep 15;94(6):828-31. doi: 10.1016/j.amjcard.2004.05.073.

Abstract

Oral L-arginine therapy reverses endothelial dysfunction and attenuates high blood pressure in hypertensive cardiac transplant recipients. L-arginine corrects derangements in the vascular endothelial nitric oxide (NO)-dependent signaling pathway. Our data support the concept that cardiac transplant recipients use excess endogenous NO from L-arginine supplementation to buffer increased vascular oxidant stress.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Arginine / administration & dosage
  • Arginine / pharmacology*
  • Child
  • Coronary Vessels / drug effects*
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / pathology
  • Female
  • Heart Transplantation*
  • Humans
  • Hypertension / drug therapy*
  • Hypertension / etiology
  • Male
  • Oxidative Stress*

Substances

  • Arginine