Sustained slowing effect of lentils on gastric emptying of solids in humans and dogs

Gastroenterology. 1992 Mar;102(3):787-92. doi: 10.1016/0016-5085(92)90159-v.


The distal small intestine is an especially potent site for carbohydrate-triggered intestinal inhibition of gastric emptying of solids. Poorly digestible carbohydrates, such as lentils, may escape proximal absorption, travel over time to reach these inhibitory mechanisms, and slow the gastric emptying of a later meal. A slowing effect on gastric emptying may be associated with a lowering effect on postprandial glucose. The aims of this study were to determine (a) whether lentils (a poorly digestible carbohydrate) vs. bread (an easily digestible carbohydrate) eaten as a premeal (with equal amounts of carbohydrates) slow the gastric emptying of a second solid meal taken 4.0-4.5 hours later and (b) whether a slowing effect on the gastric emptying of the second meal is associated with a lower postprandial glucose response. We found that in 7 dogs and 10 humans, gastric emptying of the second meal was delayed after a lentil premeal compared with a bread premeal. However, there was no difference in the glucose response to the second meal under the two conditions.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Animals
  • Diet / adverse effects*
  • Dogs
  • Fabaceae / adverse effects*
  • Female
  • Gastric Emptying / drug effects*
  • Glucose / metabolism
  • Humans
  • Male
  • Middle Aged
  • Plants, Medicinal*
  • Pylorus / drug effects


  • Glucose