Anti-inflammatory effects of vitamin E on experimental lens-induced uveitis

Int Ophthalmol. 1992 Jan;16(1):27-32. doi: 10.1007/BF00917069.


The anti-phlogistic effect of dietary vitamin E supplementation on the acute inflammation observed in experimental lens-induced uveitis in Brown Norway rats was studied. The effects of vitamin E were examined using histopathologic parameters as well as by measuring the levels of arachidonic acid metabolites. Histologic examination of the eyes revealed that the vitamin E-deficient animals had the most severe destruction of the retina, while those animals receiving the vitamin E-supplemented diet exhibited the best preservation of the retinal architecture. Levels of arachidonic acid metabolites, as determined by radioimmunoassay, were significantly higher in vitamin E deficient rats as compared with rats on a normal diet.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Arachidonic Acid / analysis
  • Choroid / chemistry
  • Choroid / pathology
  • Crystallins / analysis
  • Female
  • Radioimmunoassay
  • Rats
  • Rats, Inbred BN
  • Uveitis / drug therapy*
  • Uveitis / metabolism
  • Uveitis / pathology
  • Vitamin E / administration & dosage
  • Vitamin E / therapeutic use*
  • Vitamin E Deficiency / drug therapy
  • Vitamin E Deficiency / metabolism
  • Vitamin E Deficiency / pathology


  • Anti-Inflammatory Agents, Non-Steroidal
  • Crystallins
  • Vitamin E
  • Arachidonic Acid