DNA-microarray analysis of brain cancer: molecular classification for therapy

Nat Rev Neurosci. 2004 Oct;5(10):782-92. doi: 10.1038/nrn1518.


Primary brain tumours are among the most lethal of all cancers, largely as a result of their lack of responsiveness to current therapy. Numerous new therapies hold great promise for the treatment of patients with brain cancer, but the main challenge is to determine which treatment is most likely to benefit an individual patient. DNA-microarray-based technologies, which allow simultaneous analysis of expression of thousands of genes, have already begun to uncover previously unrecognized patient subsets that differ in their survival. Here, we review the progress made so far in using DNA microarrays to optimize brain cancer therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / genetics
  • Brain Neoplasms / classification*
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / therapy
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic / physiology
  • Genome, Human
  • Glioma / diagnosis
  • Glioma / genetics
  • Humans
  • Medulloblastoma / diagnosis
  • Medulloblastoma / genetics
  • Oligonucleotide Array Sequence Analysis / methods*
  • Reproducibility of Results


  • Biomarkers, Tumor