Angiopoietin 2 expression is related to histological grade, vascular density, metastases, and outcome in prostate cancer

Prostate. 2005 Mar 1;62(4):394-9. doi: 10.1002/pros.20163.


Background: In several malignant tissues, the angiopoietins are principal regulators of vascular growth and regression, but in normal prostate and prostate tumors the role of the angiopoietins is unknown.

Methods: Angiopoietin (ang) 1 and 2 were immunolocalized in TUR-diagnosed prostate tumors with long follow-up and the expression was related to vascular density and clinicopathological variables.

Results: Ang 1 was strongly expressed in the basal epithelial cell layer in non-malignant tissue, whereas tumors had lower levels localized to the epithelial cells. A weak ang 2 immunoreaction was observed in non-malignant tissue and in low to intermediate Gleason score (GS) tumors, with a similar expression pattern. However, most high GS tumors showed an intense ang 2 staining. Ang 2 was significantly correlated to GS, density of endoglin stained blood vessels, metastases, and to cancer specific survival.

Conclusions: We conclude that ang 2 probably is an important regulator of angiogenesis in prostate cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angiopoietin-1 / biosynthesis
  • Angiopoietin-1 / pharmacology
  • Angiopoietin-2 / biosynthesis*
  • Angiopoietin-2 / pharmacology
  • Gene Expression Profiling*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neoplasm Metastasis*
  • Neoplasm Staging
  • Neovascularization, Pathologic*
  • Prognosis
  • Prostatic Neoplasms / blood supply
  • Prostatic Neoplasms / pathology*


  • ANGPT1 protein, human
  • Angiopoietin-1
  • Angiopoietin-2