Matrix metalloproteinases and colon anastomosis repair: a new indication for pharmacological inhibition?

M S Agren; L N Jorgensen; J-M Delaissé

Matrix metalloproteinases and colon anastomosis repair: a new indication for pharmacological inhibition?

Mini Rev Med Chem. 2004 Sep;4(7):769-78.

Authors

M S Agren¹, L N Jorgensen, J-M Delaissé

Affiliation

¹ Department of Surgery K, Bispebjerg Hospital, University of Copenhagen, Denmark. maa02@bbh.hosp.dk

PMID: 15379644

Abstract

Excessive matrix metalloproteinase activities have been implicated in the pathogenesis of intestinal anastomotic dehiscence, a serious and potentially life-threatening complication following gastrointestinal surgery. In this review, the properties of matrix metalloproteinases are summarized followed by presentation of clinical therapeutic interventions with synthetic matrix metalloproteinase inhibitors and novel experimental data on colon anastomosis repair that warrant exploration of these drugs in surgical colorectal patients.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anastomosis, Surgical / adverse effects
Animals
Colorectal Neoplasms / surgery*
Enzyme Inhibitors* / chemistry
Enzyme Inhibitors* / pharmacology
Enzyme Inhibitors* / therapeutic use
Humans
Matrix Metalloproteinase Inhibitors*
Matrix Metalloproteinases / physiology
Molecular Structure
Surgical Wound Dehiscence / drug therapy*
Surgical Wound Dehiscence / enzymology
Surgical Wound Dehiscence / etiology

Substances

Enzyme Inhibitors
Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases