Changes in quality of life and self-perspective related to surgery in patients with temporal lobe epilepsy

Epilepsy Behav. 2004 Oct;5(5):735-42. doi: 10.1016/j.yebeh.2004.06.022.


Purpose: To evaluate changes in intractable epilepsy patients in terms of quality of life, depression, anxiety, stigma, and impact of epilepsy before and after surgery.

Methods: Twenty patients with intractable temporal lobe epilepsy who were waiting for surgery (pre-SAH group) and 21 patients who had already undergone surgery (post-SAH group) were studied. All patients received SF-36, Beck Depression Inventory, State-Trait Anxiety Inventory, stigma and impact of epilepsy inventories, and a form asking their own perspectives about epilepsy and surgery.

Results: Post-SAH group scored higher on all subscales of SF-36, with only RE scores being significantly better (t=-1.98, P=.05). Although depression, anxiety, and stigma scores were higher in pre-SAH group, only impact of epilepsy scores were significantly higher in pre-SAH group (t=-2.951, P=.005). Seizure frequency and comorbidity had significant effects on QOL where amount of AEDs and QOL were negatively related (r=-0.318, P<0.05). Both groups stated lack of independence and social activities as the main concern (48.8%) and recovery from epilepsy as the most important expectation from surgery (85.4%). Post-surgical group mentioned the difference in their life after surgery as independence and increase in social activities (47.6%).

Conclusion: QOL of patients after surgery was found to be better than before surgery. Results also revealed that seizure frequency, comorbidity, and anti-epileptic medication affected health related QOL negatively. Impact of epilepsy levels was found to be higher among the pre-SAH patients. Finally, independence seemed to be the most important concern and gain for Turkish epilepsy patients.

MeSH terms

  • Adult
  • Amygdala / surgery
  • Anticonvulsants / administration & dosage
  • Anticonvulsants / therapeutic use
  • Anxiety / etiology
  • Anxiety / psychology
  • Comorbidity
  • Cross-Sectional Studies
  • Drug Resistance
  • Epilepsy, Temporal Lobe / complications
  • Epilepsy, Temporal Lobe / psychology*
  • Epilepsy, Temporal Lobe / surgery*
  • Female
  • Health
  • Hippocampus / surgery
  • Humans
  • Male
  • Neurosurgical Procedures*
  • Psychiatric Status Rating Scales
  • Quality of Life*
  • Seizures / epidemiology
  • Treatment Outcome
  • Turkey


  • Anticonvulsants