Long-term metabolic, cardiovascular and neoplastic risks with polycystic ovary syndrome

Best Pract Res Clin Obstet Gynaecol. 2004 Oct;18(5):803-12. doi: 10.1016/j.bpobgyn.2004.05.005.


Metabolic abnormalities and obesity have long been associated with the development of cardiovascular disease in the general population. These same features are also associated with polycystic ovary syndrome (PCOS). An increased prevalence of hypertension, dyslipidaemia, obesity and hyperinsulinaemia, as well as changes in coagulation and blood vessel function, provide an explanation as to why women with PCOS are at an increased risk of developing cardiovascular disease over the long term.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / etiology*
  • Female
  • Humans
  • Metabolic Syndrome / etiology
  • Neoplasms / etiology*
  • Obesity / complications
  • Polycystic Ovary Syndrome / complications*
  • Polycystic Ovary Syndrome / physiopathology
  • Polycystic Ovary Syndrome / therapy
  • Risk Factors