Evidence for a dysfunctional retrosplenial cortex in patients with schizophrenia: a functional magnetic resonance imaging study with a semantic-perceptual contrast

Neurosci Lett. 2004 Oct 7;369(1):4-8. doi: 10.1016/j.neulet.2004.07.024.


We investigated whether the retrosplenial and the posterior cingulate cortex (RS-PCC) is functionally impaired in schizophrenia patients. Therefore, we measured functional magnetic resonance imaging (fMRI) signal changes associated with a synonym-judgment task known to activate, among other areas, the RS-PCC. Compared to 12 matched control subjects, 12 schizophrenia patients exhibited reliably weaker activations in the RS-PCC, the dorsolateral prefrontal cortex and the left orbitofrontal cortex (P < 0.05, corrected). Differences in frontal activations are in line with previous studies showing a structurally and functionally affected prefrontal cortex in schizophrenia. The impaired RS-PCC functionality in a semantic task may relate to verbal memory deficits frequently observed in schizophrenia patients, because this region is pivotal for gating information into the medial temporal lobe memory system.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Mapping
  • Case-Control Studies
  • Frontal Lobe / anatomy & histology
  • Frontal Lobe / blood supply
  • Frontal Lobe / physiopathology
  • Functional Laterality
  • Humans
  • Judgment / physiology*
  • Limbic System / anatomy & histology
  • Limbic System / blood supply
  • Limbic System / physiopathology*
  • Magnetic Resonance Imaging / methods
  • Male
  • Neuropsychological Tests / statistics & numerical data
  • Oxygen / blood
  • Schizophrenia / blood
  • Schizophrenia / physiopathology*
  • Semantics*


  • Oxygen