Mouse models of human cancer as tools in drug development

Cancer Cell. 2004 Sep;6(3):197-8. doi: 10.1016/j.ccr.2004.09.004.


Histologically accurate mouse models of human cancers generated by somatic or germline genetic modification strategies recapitulate the genetic alterations found in human tumors. In this issue of Cancer Cell, test a novel signaling inhibitor in a genetically defined mouse medulloblastoma and show the utility of these models in drug development. They demonstrate that targeting signaling components downstream of tumor initiating mutations can be an effective therapeutic strategy for solid tumors.

Publication types

  • Comment

MeSH terms

  • Animals
  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / genetics*
  • Disease Models, Animal*
  • Drug Design*
  • Drug Screening Assays, Antitumor
  • Germ-Line Mutation
  • Medulloblastoma / drug therapy
  • Medulloblastoma / genetics*
  • Mice
  • Mice, Transgenic*
  • Neoplasms, Experimental
  • Signal Transduction / drug effects