Latent TGF-beta binding proteins

Int J Biochem Cell Biol. 2005 Jan;37(1):38-41. doi: 10.1016/j.biocel.2004.03.011.

Abstract

Latent TGF-beta binding proteins are multidomain proteins with a common, highly repetitive structural organization and partially overlapping expression patterns. Latent TGF-beta binding protein-1, -3 and -4 bind latent TGF-beta. TGF-betas are normally secreted as latent complexes, consisting of the mature TGF-beta dimer non-covalently bound to its processed propeptide dimer plus a latent TGF-beta binding protein. The latent TGF-beta binding protein is covalently bound to the propeptide. These binding proteins may perform at least two functions: structural, as components of the matrix, and regulatory, as modulators of TGF-beta availability.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Extracellular Matrix / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins / chemistry
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Latent TGF-beta Binding Proteins
  • Protein Binding
  • Protein Isoforms / chemistry
  • Protein Isoforms / metabolism
  • Protein Structure, Tertiary
  • Signal Transduction / physiology
  • Transforming Growth Factor beta / metabolism*

Substances

  • Intracellular Signaling Peptides and Proteins
  • Latent TGF-beta Binding Proteins
  • Protein Isoforms
  • Transforming Growth Factor beta