Review
doi: 10.1152/physiol.00010.2004.
Why calcium-stimulated adenylyl cyclases?
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- PMID: 15381755
- DOI: 10.1152/physiol.00010.2004
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Review
Why calcium-stimulated adenylyl cyclases?
Physiology (Bethesda).
2004 Oct.
Free article
Abstract
The Ca(2+)/calmodulin-stimulated adenylyl cyclases, AC1 and AC8, play a critical role in several forms of neuroplasticity, including long-lasting long-term potentiation (L-LTP) and long-term memory (LTM). By coupling neuronal activity and Ca(2+) increases to the production of cAMP, AC1 and AC8 activate cAMP-dependent signal transduction and transcriptional pathways critical for L-LTP and LTM.
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