CuBr-catalyzed efficient alkynylation of sp3 C-H bonds adjacent to a nitrogen atom

Zhiping Li; Chao-Jun Li

doi:10.1021/ja0460763

CuBr-catalyzed efficient alkynylation of sp3 C-H bonds adjacent to a nitrogen atom

J Am Chem Soc. 2004 Sep 29;126(38):11810-1. doi: 10.1021/ja0460763.

Authors

Zhiping Li¹, Chao-Jun Li

Affiliation

¹ Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.

PMID: 15382913
DOI: 10.1021/ja0460763

Abstract

A simple and effective catalytic method to construct propargylamine was developed by using copper bromide and tert-BuOOH via a combination of sp3 C-H bond and sp C-H bond activations followed by C-C bond formation.