Paxillin: Adapting to Change

Physiol Rev. 2004 Oct;84(4):1315-39. doi: 10.1152/physrev.00002.2004.

Abstract

Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and integration of multiple signaling pathways to effect the optimal cellular response to changes in the immediate environment. Paxillin is a multidomain adaptor that recruits both structural and signaling molecules to focal adhesions, sites of integrin engagement with the extracellular matrix, where it performs a critical role in transducing adhesion and growth factor signals to elicit changes in cell migration and gene expression.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Adhesion / physiology
  • Cell Division / physiology
  • Cell Movement / physiology
  • Cytoskeletal Proteins / chemistry*
  • Cytoskeletal Proteins / physiology*
  • Extracellular Matrix / physiology
  • Growth Substances / physiology
  • Humans
  • Integrins / physiology
  • Paxillin
  • Phosphoproteins / chemistry*
  • Phosphoproteins / physiology*
  • Signal Transduction / physiology*

Substances

  • Cytoskeletal Proteins
  • Growth Substances
  • Integrins
  • PXN protein, human
  • Paxillin
  • Phosphoproteins