doi: 10.1038/355609a0.
Cloning and domain structure of the mammalian splicing factor U2AF
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- PMID: 1538748
- DOI: 10.1038/355609a0
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Cloning and domain structure of the mammalian splicing factor U2AF
Nature.
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Abstract
A complementary DNA clone encoding the large subunit of the essential mammalian pre-messenger RNA splicing component U2 snRNP auxiliary factor (U2AF65) has been isolated and expressed in vitro. It contains two functional domains: a sequence-specific RNA-binding region composed of three ribonucleoprotein-consensus sequence domains, and an arginine/serine-rich motif necessary for splicing but not for binding to pre-mRNA.
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