Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 355 (6361), 609-14

Cloning and Domain Structure of the Mammalian Splicing Factor U2AF

Affiliations

Cloning and Domain Structure of the Mammalian Splicing Factor U2AF

P D Zamore et al. Nature.

Abstract

A complementary DNA clone encoding the large subunit of the essential mammalian pre-messenger RNA splicing component U2 snRNP auxiliary factor (U2AF65) has been isolated and expressed in vitro. It contains two functional domains: a sequence-specific RNA-binding region composed of three ribonucleoprotein-consensus sequence domains, and an arginine/serine-rich motif necessary for splicing but not for binding to pre-mRNA.

Similar articles

See all similar articles

Cited by 245 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback