Facile synthesis of 2-substituted 1,2-dihydro-1-naphthols and 2-substituted 1-naphthols

Chi-Li Chen; Stephen F Martin

doi:10.1021/ol048517t

Facile synthesis of 2-substituted 1,2-dihydro-1-naphthols and 2-substituted 1-naphthols

Org Lett. 2004 Sep 30;6(20):3581-4. doi: 10.1021/ol048517t.

Authors

Chi-Li Chen¹, Stephen F Martin

Affiliation

¹ Department of Chemistry and Biochemistry, The University of Texas, Austin, Texas 78712, USA.

PMID: 15387553
DOI: 10.1021/ol048517t

Abstract

[reaction: see text] The palladium-catalyzed ring opening of dimethoxy oxabenzonorbornadiene with aryl or vinyl halides occurred under very mild conditions to give substituted 1,2-dihydronaphthols that were oxidized with IBX to furnish substituted naphthols in excellent overall yields.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Catalysis
Combinatorial Chemistry Techniques
Naphthols / chemical synthesis*
Palladium / chemistry*

Substances

Naphthols
Palladium