Alternative quality control for technetium-99m IDA complexes

Appl Radiat Isot. 2004 Dec;61(6):1151-5. doi: 10.1016/j.apradiso.2004.03.101.


A quality control procedure for 99mTc-IDA complexes based on the use of C18 Sep-pak cartridges is developed and the validation of the procedure presented. C18 Sep-pak cartridges are pretreated by washing with 95% ethanol followed by 10(-3) N hydrochloric acid. A small amount of the 99mTc-IDA complex is applied, washed with 10(-3) N hydrochloric acid and eluted with 95% ethanol. The radiochemical purity values obtained for 99mTc-mebrofenin and 99mTc-disofenin using this Sep-pak procedure are comparable to those obtained using the standard two strip (ITLC-SG/100% methanol, ITLC-SA/20% saline) procedure.

Publication types

  • Comparative Study
  • Evaluation Study
  • Validation Study

MeSH terms

  • Chromatography, Thin Layer / methods*
  • Imino Acids / analysis*
  • Imino Acids / chemistry*
  • Organotechnetium Compounds / analysis*
  • Organotechnetium Compounds / chemistry*
  • Quality Assurance, Health Care / methods*
  • Radiopharmaceuticals / analysis
  • Radiopharmaceuticals / chemistry
  • Silicon Dioxide / chemistry*


  • Imino Acids
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • technetium Tc 99m iminodiacetic acid
  • Silicon Dioxide
  • octadecyl silane-bonded silica