Daptomycin is highly efficacious against penicillin-resistant and penicillin- and quinolone-resistant pneumococci in experimental meningitis

Antimicrob Agents Chemother. 2004 Oct;48(10):3928-33. doi: 10.1128/AAC.48.10.3928-3933.2004.

Abstract

The penetration of daptomycin, a new lipopeptide antibiotic, into inflamed meninges ranged between 4.37 and 7.53% (mean, 5.97%). Daptomycin was very efficacious in the treatment of experimental pneumococcal meningitis, producing a decrease of -1.20 +/- 0.32 Deltalog(10) CFU/ml. h in the bacterial titer of Streptococcus pneumoniae against a penicillin-resistant strain and of -0.97 +/- 0.32 Deltalog(10) CFU/ml. h against a penicillin- and quinolone-resistant strain found in cerebrospinal fluid (CSF). For both strains, daptomycin was significantly superior to the standard regimen of a combination of ceftriaxone with vancomycin, sterilizing 9 of 10 CSF samples after 4 h. In vitro, daptomycin produced highly bactericidal activity in concentrations above the MIC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / cerebrospinal fluid
  • Anti-Bacterial Agents / pharmacokinetics
  • Anti-Bacterial Agents / therapeutic use*
  • Anti-Infective Agents / pharmacology*
  • Area Under Curve
  • Daptomycin / cerebrospinal fluid
  • Daptomycin / pharmacokinetics
  • Daptomycin / therapeutic use*
  • Dose-Response Relationship, Drug
  • Drug Resistance, Bacterial
  • Kinetics
  • Meninges / metabolism
  • Meningitis, Pneumococcal / drug therapy*
  • Meningitis, Pneumococcal / metabolism
  • Meningitis, Pneumococcal / microbiology
  • Mutation / genetics
  • Penicillin Resistance*
  • Quinolones / pharmacology*
  • Rabbits
  • Streptococcus pneumoniae / drug effects
  • Streptococcus pneumoniae / genetics
  • Vancomycin / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Quinolones
  • Vancomycin
  • Daptomycin