Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS

Ann Neurol. 2004 Oct;56(4):564-7. doi: 10.1002/ana.20223.


Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with the death of motor neurons in the spinal cord and brainstem. The cause of ALS is unknown and there is no cure. This study demonstrates, for the first time, that vascular endothelial growth factor (VEGF) delays progression of symptoms and prolongs survival in a Cu/Zn superoxide dismutase (SOD1) transgenic mouse model of ALS. These observations suggest that VEGF or related compounds, might be of value in the treatment of ALS patients.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Alanine / genetics
  • Amyotrophic Lateral Sclerosis / drug therapy*
  • Amyotrophic Lateral Sclerosis / genetics
  • Animals
  • Disease Models, Animal
  • Glycine / genetics
  • Humans
  • Mice
  • Mice, Transgenic / physiology*
  • Motor Activity / drug effects
  • Mutation / genetics
  • Probability
  • Superoxide Dismutase / genetics
  • Superoxide Dismutase-1
  • Survival Analysis
  • Vascular Endothelial Growth Factor A / therapeutic use*


  • SOD1 protein, human
  • Vascular Endothelial Growth Factor A
  • Sod1 protein, mouse
  • Superoxide Dismutase
  • Superoxide Dismutase-1
  • Alanine
  • Glycine