Switching from ergot to nonergot dopamine agonists in Parkinson's disease: a clinical series and five-drug dose conversion table

Mov Disord. 2004 Nov;19(11):1370-4. doi: 10.1002/mds.20210.

Abstract

Of 99 patients on ergot-derived dopamine agonists informed about possible long-term side effects, switching to a nonergot was undertaken in 88 (89%). There were adverse events in 26%. After 11 months, 82% were on their switch agonist and 93% were on any agonist. Switching dopamine agonists is feasible in this population.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Adverse Drug Reaction Reporting Systems
  • Antiparkinson Agents / administration & dosage*
  • Antiparkinson Agents / adverse effects
  • Benzothiazoles
  • Bromocriptine / administration & dosage
  • Bromocriptine / adverse effects
  • Cabergoline
  • Domperidone / administration & dosage
  • Domperidone / adverse effects
  • Dopamine Agonists / administration & dosage*
  • Dopamine Agonists / adverse effects
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Ergolines / administration & dosage
  • Ergolines / adverse effects
  • Ergot Alkaloids / administration & dosage*
  • Ergot Alkaloids / adverse effects
  • Feasibility Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Indoles / administration & dosage
  • Indoles / adverse effects
  • Levodopa / administration & dosage
  • Levodopa / adverse effects
  • Male
  • Middle Aged
  • Parkinson Disease / diagnosis
  • Parkinson Disease / drug therapy*
  • Pergolide / administration & dosage
  • Pergolide / adverse effects
  • Pramipexole
  • Therapeutic Equivalency
  • Thiazoles / administration & dosage
  • Thiazoles / adverse effects

Substances

  • Antiparkinson Agents
  • Benzothiazoles
  • Dopamine Agonists
  • Ergolines
  • Ergot Alkaloids
  • Indoles
  • Thiazoles
  • ropinirole
  • Pergolide
  • Bromocriptine
  • Levodopa
  • Domperidone
  • Pramipexole
  • Cabergoline