Rebound psychosis: effect of discontinuation of antipsychotics in Parkinson's disease

Mov Disord. 2005 Jan;20(1):104-5. doi: 10.1002/mds.20260.


To determine whether psychiatrically stable patients with a history of drug-induced psychosis could be successfully weaned off their antipsychotic drug, we offered consecutive Parkinson disease (PD) patients on quetiapine or clozapine, who were free of any on-going psychosis, to be slowly weaned off their antipsychotic drug. Before the study was aborted 6 PD patients (mean age, 78 years) with an average antipsychotic exposure of 20 months (5 on quetiapine, 1 on clozapine) were enrolled. After the antipsychotic agent was discontinued, psychosis recurred in 5 of 6 patients. In 3 patients the "rebound psychosis" was worse than the original psychotic episode and required subsequent higher antipsychotic medication doses.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antipsychotic Agents / adverse effects*
  • Brief Psychiatric Rating Scale
  • Clozapine / adverse effects*
  • Dibenzothiazepines / adverse effects*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Tolerance
  • Female
  • Humans
  • Male
  • Parkinson Disease / complications*
  • Prospective Studies
  • Psychotic Disorders / complications
  • Psychotic Disorders / drug therapy*
  • Quetiapine Fumarate
  • Recurrence
  • Time Factors


  • Antipsychotic Agents
  • Dibenzothiazepines
  • Quetiapine Fumarate
  • Clozapine