Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting "sleep attacks"

Mov Disord. 2004 Nov;19(11):1279-84. doi: 10.1002/mds.20245.


Genes encoding proteins involved in dopaminergic transmission are potential candidate genes for the induction of somnolence in Parkinson's disease (PD) because dopaminergic agents have been shown to be associated with sudden onset of sleep (SOS) in PD. We conducted an association study on dopamine D2, D3, and D4 receptor gene polymorphisms comparing 137 PD patients with SOS and 137 PD patients without SOS matched according to drug therapy, disease duration, sex, and age. Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD. No significant association between two other investigated polymorphisms and the phenomenon of "sleep attacks" in PD was observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alleles
  • Antiparkinson Agents / adverse effects
  • Antiparkinson Agents / therapeutic use
  • Disorders of Excessive Somnolence / chemically induced
  • Disorders of Excessive Somnolence / genetics*
  • Dopamine Agonists / adverse effects
  • Dopamine Agonists / therapeutic use
  • Female
  • Gene Frequency / genetics
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Narcolepsy / chemically induced
  • Narcolepsy / genetics*
  • Parkinson Disease / drug therapy
  • Parkinson Disease / genetics
  • Pilot Projects
  • Polymorphism, Genetic / drug effects
  • Polymorphism, Genetic / genetics*
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / genetics*
  • Receptors, Dopamine D2 / drug effects
  • Receptors, Dopamine D2 / genetics
  • Receptors, Dopamine D3
  • Receptors, Dopamine D4
  • Risk Factors


  • Antiparkinson Agents
  • DRD3 protein, human
  • DRD4 protein, human
  • Dopamine Agonists
  • Receptors, Dopamine
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • Receptors, Dopamine D4