Cannabinoid signaling in glial cells

Glia. 2004 Dec;48(4):267-77. doi: 10.1002/glia.20084.


The cannabinoid signaling system is composed of cannabinoid (CB) receptors, their endogenous ligands, the endocannabinoids, and the enzymes that produce and inactivate them. It is well known that neurons communicate between each other through this signaling system. Delta 9-tetrahydrocannabinol, the main psychoactive compound of marijuana, interacts with CB receptors, impinging on this communication and inducing profound behavioral effects such as memory impairment and analgesia. Recent evidence suggests that glial cells also express components of the cannabinoid signaling system and marijuana-derived compounds act at CB receptors expressed by glial cells, affecting their functions. This review summarizes this evidence, discusses how glial cells might use the cannabinoid signaling system to communicate with neighboring cells, and argues that nonpsychotropic cannabinoids, both marijuana-derived and synthetic, likely constitute lead compounds for therapy aimed at reducing acute and chronic neuroinflammation, such as occurs in multiple sclerosis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cannabinoids / chemistry
  • Cannabinoids / metabolism*
  • Humans
  • Neuroglia / metabolism*
  • Receptors, Cannabinoid / chemistry
  • Receptors, Cannabinoid / metabolism
  • Signal Transduction / physiology*


  • Cannabinoids
  • Receptors, Cannabinoid