Successful resuscitation and neurologic recovery from refractory ventricular fibrillation after magnesium sulfate administration

Ann Emerg Med. 1992 Jan;21(1):92-6. doi: 10.1016/s0196-0644(05)82249-8.


A 46-year-old man suffered a witnessed cardiac arrest. Ventricular fibrillation persisted despite 62 minutes of basic and advanced cardiac life support measures in the field. On arrival in the emergency department, he received 4 g magnesium sulfate IV and was defibrillated successfully to normal sinus rhythm with the next countershock. The patient was discharged neurologically intact. We discuss the possible mechanisms of action and clinical use of IV magnesium sulfate in cardiac arrest.

Publication types

  • Case Reports

MeSH terms

  • Cardiopulmonary Resuscitation
  • Electric Countershock
  • Heart Arrest / drug therapy
  • Heart Arrest / etiology
  • Heart Arrest / therapy
  • Humans
  • Magnesium Sulfate / therapeutic use*
  • Male
  • Middle Aged
  • Nervous System / physiopathology
  • Ventricular Fibrillation / complications
  • Ventricular Fibrillation / drug therapy*
  • Ventricular Fibrillation / therapy


  • Magnesium Sulfate