The effect of relaxin on tissue expansion

Arch Otolaryngol Head Neck Surg. 1992 Feb;118(2):153-6. doi: 10.1001/archotol.1992.01880020047014.


Relaxin is a 56-amino acid polypeptide that produces relaxation of the pubic ligament. Ten young male pigs were implanted with tissue expanders and osmotic pumps. The pumps in five animals contained recombinant human relaxin to produce a serum relaxin level of 1 ng/mL. The other five pumps contained saline. Repeated measurements of the pressure-volume expansion curves showed a significant decrease in the pressure needed to fill the expanders in the relaxin group compared with the control group. Dermal thickness in the control group and epidermal thickness in both control and experimental groups were increased on histomorphometric measurement. No adverse effects were seen in the relaxin group. Relaxin facilitates tissue expansion in pigs without affecting dermal thickness.

MeSH terms

  • Animals
  • Male
  • Recombinant Proteins / blood
  • Recombinant Proteins / pharmacology
  • Relaxin / blood
  • Relaxin / pharmacology*
  • Skin / drug effects
  • Swine
  • Tissue Expansion*


  • Recombinant Proteins
  • Relaxin