HIV-1 protease cleaves actin during acute infection of human T-lymphocytes

AIDS Res Hum Retroviruses. 1992 Feb;8(2):291-5. doi: 10.1089/aid.1992.8.291.

Abstract

Actin, one of the most abundant proteins of the cell, is hydrolyzed by the human immunodeficiency virus type 1 (HIV-1) protease during acute infection of cultured human T lymphocytes. The actin fragments produced during the course of infection are identical to those obtained by recombinant HIV-1 protease digests of (1) a lysate from uninfected T lymphocytes and (2) globular actin itself. Hydrolysis by the HIV-1 protease of physiologically important host cellular proteins during infection may have important consequences relative to viral pathogenesis.

MeSH terms

  • Actins / metabolism*
  • Cell Line
  • Electrophoresis, Gel, Two-Dimensional
  • HIV Protease / metabolism*
  • HIV-1 / enzymology*
  • HIV-1 / physiology
  • Humans
  • Hydrolysis
  • T-Lymphocytes / microbiology

Substances

  • Actins
  • HIV Protease