Antioxidative activity of synthetic melanins. Cardiolipin liposome model

Biochim Biophys Acta. 1992 Mar 5;1116(1):11-6. doi: 10.1016/0304-4165(92)90121-a.

Abstract

The inhibiting effect of melanin synthesized from dihydroxyphenylalanine (DOPA), dopamine, adrenaline and adrenolutin on the ultraviolet- or the Fe(2+)-ascorbic acid-induced peroxidation of cardiolipin liposomes has been studied. All these melanins are able to inhibit both the ultraviolet- and the Fe(2+)-ascorbic acid-induced lipid peroxidation. Antioxidative activity of melanins enhances in the order: dopamine-melanin less than melanin synthesized from dopamine in the presence of Cu(2+) less than DOPA--melanin less than melanin synthesized from adrenaline in the presence of Cu(2+) approximately equal to adrenolutin-melanin, and correlates with their ability to scavenge superoxide anion radical. The optical screening effect of the investigated melanins in the inhibition of lipid peroxidation was not higher than 15% for the most active melanins.

Publication types

  • Comparative Study

MeSH terms

  • Antioxidants / pharmacology*
  • Ascorbic Acid
  • Cardiolipins / chemistry*
  • Cardiolipins / radiation effects
  • Dihydroxyphenylalanine / analogs & derivatives*
  • Dihydroxyphenylalanine / chemical synthesis
  • Dihydroxyphenylalanine / pharmacology
  • Dopamine / analogs & derivatives
  • Dopamine / pharmacology
  • Epinephrine / analogs & derivatives
  • Epinephrine / pharmacology
  • Ferrous Compounds
  • Indoles / pharmacology
  • Lipid Peroxidation / drug effects
  • Liposomes / chemistry*
  • Melanins / chemical synthesis
  • Melanins / pharmacology*
  • Nitroblue Tetrazolium / chemistry
  • Photochemistry
  • Ultraviolet Rays

Substances

  • Antioxidants
  • Cardiolipins
  • Ferrous Compounds
  • Indoles
  • Liposomes
  • Melanins
  • iron(II)-ascorbic acid complex
  • neuromelanin
  • adrenolutin
  • Nitroblue Tetrazolium
  • Dihydroxyphenylalanine
  • DOPA melanin
  • Ascorbic Acid
  • Dopamine
  • Epinephrine