Monitoring of serum KL-6 antigen in a patient with radiation pneumonia

Chest. 1992 Mar;101(3):858-60. doi: 10.1378/chest.101.3.858.


Serum marker KL-6 antigen has been reported to be a valuable indicator of the disease activity of interstitial pneumonia. It is not clear how sensitive the serum KL-6 antigen level is in reflecting histologic changes in lung tissues. We report here the results of serial measurements of serum KL-6 antigen in a 76-year-old male patient with radiation pneumonia. Serum KL-6 antigen levels were more sensitive than lactate dehydrogenase and procollagen type III N-terminal peptide. The level of serum KL-6 antigen appears to reflect the histologic changes of the lung more sensitively than does C-reactive protein.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antigens / blood*
  • Antigens, Neoplasm
  • Biomarkers / blood
  • C-Reactive Protein / analysis
  • Glycoproteins*
  • Humans
  • L-Lactate Dehydrogenase / blood
  • Lung Neoplasms / radiotherapy
  • Male
  • Mucin-1
  • Mucins
  • Peptide Fragments / blood
  • Procollagen / blood
  • Pulmonary Fibrosis / diagnosis*
  • Pulmonary Fibrosis / diagnostic imaging
  • Pulmonary Fibrosis / etiology
  • Radiation Injuries / diagnosis*
  • Radiography


  • Antigens
  • Antigens, Neoplasm
  • Biomarkers
  • Glycoproteins
  • MUC1 protein, human
  • Mucin-1
  • Mucins
  • Peptide Fragments
  • Procollagen
  • procollagen Type III-N-terminal peptide
  • C-Reactive Protein
  • L-Lactate Dehydrogenase