Can non-REM sleep be depressogenic?

J Affect Disord. 1992 Feb;24(2):101-8. doi: 10.1016/0165-0327(92)90024-z.


Sleep and mood are clearly interrelated in major depression, as shown by the antidepressive effects of various experiments, such as total sleep deprivation, partial sleep deprivation, REM sleep deprivation, and temporal shifts of the sleep period. The prevailing hypotheses explaining these effects concern the antidepressant potency of the suppression of either REM sleep or non-REM sleep. This issue is discussed in the light of present knowledge of the kinetics of non-REM sleep intensity, REM sleep production, and their interaction. Recent findings have led us to suggest that the suppression of non-REM sleep intensity is the common pathway in the set of experimental data on the antidepressant effects of sleep manipulations.

MeSH terms

  • Antidepressive Agents, Tricyclic / therapeutic use
  • Benzodiazepines / therapeutic use
  • Clomipramine / therapeutic use
  • Depressive Disorder / drug therapy
  • Depressive Disorder / etiology
  • Depressive Disorder / physiopathology*
  • Electroencephalography
  • Female
  • Humans
  • Male
  • Sleep / drug effects
  • Sleep / physiology
  • Sleep Deprivation / physiology
  • Sleep Wake Disorders / drug therapy
  • Sleep Wake Disorders / etiology
  • Sleep Wake Disorders / physiopathology*
  • Sleep, REM / drug effects
  • Sleep, REM / physiology*


  • Antidepressive Agents, Tricyclic
  • Benzodiazepines
  • Clomipramine