Interferon alpha-induced changes in Fc gamma R-specific mRNA expression and isotype-specific, Fc gamma R-mediated phagocytosis in C3H/OuJ (Lpsn) and C3H/HeJ (Lpsd) macrophages

J Leukoc Biol. 1992 Mar;51(3):300-4. doi: 10.1002/jlb.51.3.300.

Abstract

Peritoneal exudate macrophages from C3H/OuJ (Lpsn) and C3H/HeJ (Lpsd) mice were treated with interferon alpha (IFN-alpha), and isotype-specific phagocytosis and gene expression were measured. IFN-alpha selectively augments phagocytosis of IgG2a, with a highly significant induction of Fc gamma RI mRNA expression, while parallel Fc gamma RIII alpha measurements show a relatively small increase.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibody Specificity
  • Female
  • Immunoglobulin Isotypes / immunology*
  • Interferon-alpha / pharmacology*
  • Macrophages / immunology*
  • Mice
  • Mice, Inbred C3H
  • Phagocytosis / immunology*
  • RNA, Messenger / analysis
  • RNA, Messenger / drug effects
  • Receptors, Fc / genetics*
  • Receptors, Fc / physiology

Substances

  • Immunoglobulin Isotypes
  • Interferon-alpha
  • RNA, Messenger
  • Receptors, Fc