Prevalence and pathologic features of sickle cell nephropathy and response to inhibition of angiotensin-converting enzyme

N Engl J Med. 1992 Apr 2;326(14):910-5. doi: 10.1056/NEJM199204023261402.


Background: Nephropathy may develop in patients with sickle cell disease. We determined the prevalence of proteinuria and renal insufficiency in a group of patients with sickle cell disease and investigated the renal pathologic changes and the effects of an angiotensin-converting-enzyme inhibitor (enalapril) on protein excretion in patients found to have nephropathy.

Methods: We prospectively screened 381 patients with sickle cell disease for the presence of proteinuria and renal insufficiency. Renal biopsy and measurements of glomerular filtration rate, effective renal plasma flow, and urinary protein excretion were performed in 10 patients with mild nephropathy before and after the administration of enalapril, and again two to three weeks after its discontinuation.

Results: Of the 381 patients with sickle cell disease, 26 (7 percent) had serum creatinine concentrations above the normal range and 101 (26 percent) had proteinuria of at least 1+. The renal lesions in the 10 patients who had biopsies consisted of glomerular enlargement and perihilar focal segmental glomerulosclerosis. The mean (+/- SD) glomerular area in these patients was 28.7 +/- 4.1 x 10(3) micron 2, as compared with 15.8 +/- 4.3 x 10(3) micron 2 in 10 control patients without renal disease who had died of trauma (P less than 0.0001). During the administration of enalapril, the mean 24-hour urinary protein excretion decreased 57 percent (range, 23 to 79 percent) below the base-line value (P less than 0.001), and it increased to 25 percent below the base-line value after enalapril was discontinued. The glomerular filtration rate and effective renal plasma flow did not change significantly.

Conclusions: Approximately 25 percent of patients with sickle cell disease have proteinuria. Treatment with enalapril reduces the degree of proteinuria in these patients, suggesting that glomerular capillary hypertension may be a pathogenic factor in sickle cell nephropathy.

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Anemia, Sickle Cell / complications*
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
  • Child
  • Creatinine / blood
  • Enalapril / therapeutic use
  • Female
  • Glomerular Filtration Rate
  • Glomerulosclerosis, Focal Segmental / pathology
  • Humans
  • Kidney / pathology
  • Kidney Diseases / drug therapy
  • Kidney Diseases / epidemiology*
  • Kidney Diseases / pathology
  • Male
  • Middle Aged
  • Prospective Studies
  • Proteinuria / drug therapy
  • Proteinuria / epidemiology
  • Proteinuria / pathology


  • Angiotensin-Converting Enzyme Inhibitors
  • Enalapril
  • Creatinine